The lower limit of quantitation was 0. 3 ngmL. Pre dose trough samples collecte

The daily energy requirement was estimated from REE or BEE by multiply ing by stress and activity coefficients of 1. 1 and 1. 3, re spectively. The stress coefficient was selected between no stress. 1. 0 and suffering from advanced cancer. 1. 2, while the activity coefficient was decided Amuvatinib 臨床試験 between simple walk ing. 1. 2 and light labour. 1. 4, respectively. The protein and energy malnutrition was diagnosed in the case that npRQ was less than 0. 85 as well as nitrogen balance was negative. Normalization of therapeutic invasiveness using prothrombin time In order to standardize a recovery speed form HCC treat ments based on therapeutic intensity, a reduction rate of prothrombin time was used as an indicator for the intensity.<br><br> Given nadir as a day showing minimum value of PT INR after finishing an entire series of treatment against HCC in one admission, a reduction rate of PT INR was defined as a reduction percentage of PT INR at nadir against PT INR on admission. The formula calculating PT INR reduction rate AT-406 代理店 is as follows where PT INRad and PT INRnad indicate PT INR on admission and at the nadir after a series of treatment, respectively. PT INR reduction rate PT INRad 100 Then, a recovery speed from treatments for HCC was evaluated based on a length of hospital satay after nadir that was normalized by dividing with the PT INR reduction rate as follows. Recovery speed hospital stay after PT INRnadPT INR reduction rate 100 Statistical analysis Categorical data were compared between two groups using paired or unpaired t tests when groups were matched or unmatched, respectively.<br><br> Correlation between npRQ and various factors were analyzed by calculating the Pearson correlation coefficient. All analyses were performed using GraphPad Prism 6 software except for AG-490 臨床試験 a multivariate lin ear regression analysis, for which PASW statics 17. 0 was used, and a two sided P value less than 0. 05 was considered statistically significant. Results Patients hospitalized for hepatocellular carcinoma treatments frequently suffered from protein energy malnutrition. Patients who were admitted for active treatment of HCC had a home diet with an average of 1977 513 kcalday leading to a negative nitrogen balance of − 2. 1 4. 5 gdl. Because among 35 cases, a case could not properly collect urine sample for a day on admission causing loss of UUN data, nitrogen balance and REE were evaluated for 34 cases.<br><br> The energy malnutrition was also observed in the average npRQ value of 0. 83 0. 061 on day 1, which was estimated to reflect the energy status at home. npRQ on day 1 was not significantly correlated with BMI of 24. 3 3. 2 kgm2 nor other representative body composition markers such as intra and extra cellular water, percent body fat or soft lean mass. The average energy intake in the hospital was 1834 290 kcalday and tended to be lower than that at home. However, the negative nitrogen balance of −3. 0 2. 8 gdl was not significantly different, and the energy state was even significantly improved to a normal range of npRQ on day 4 at 0. 86 0. 075. The energy requirements were calculated by multiplying 1. 1 and 1. 3 as stress and activity coefficients, respectively, to REE or BEE, which resulted into 1940 385 kcal or 1860 281 kcalday, re spectively.